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Favipiravir and Ribavirin protect immunocompetent mice from lethal CCHFV infection
In this study, we describe a lethal model of CCHFV infection using a mouse-adapted strain of CCHFV (MA-CCHFV) in adult wild-type male mice. Infected mice developed high viral loads, tissue pathology, inflammatory immune responses before ultimately succumbing to the infection. We used the model to evaluate the protective efficacy of nucleoside analogs monulpiravir, favipiravir, ribavirin, the antibiotic tigecycline and the corticosteroids dexamethasone and methylprednisolone against lethal CCHFV infection. Tigecycline, monulpiravir and the corticosteroids failed to protect mice from lethal MA-CCHFV infection. In contrast, f...
Source: Antiviral Research - August 23, 2023 Category: Virology Authors: Thomas Tipih Kimberly Meade-White Deepashri Rao Trenton Bushmaker Mathew Lewis Carl Shaia Heinz Feldmann David W Hawman Source Type: research

COVID-19 vaccine-associated myositis: a comprehensive review of the literature driven by a case report
AbstractSeveral cases of vaccine-associated manifestations have been published including cases of inflammatory myositis. Herein, we comprehensively review the literature on the occasion of case of a woman with inflammatory myositis following COVID-19 vaccination. A 67-year-old woman presented with left arm edema, rash, and weakness after the 2nd dose of the BTN162b2 vaccine. Raised muscle enzymes and inflammatory markers with muscle edema on MRI and myositis findings on the electromyogram established the diagnosis. She was successfully treated with methylprednisolone pulses, intravenous immunoglobulin, methotrexate, and hy...
Source: Immunologic Research - August 1, 2023 Category: Allergy & Immunology Source Type: research

Vaccination approach in patients with an allergic reaction to COVID-19 vaccines or at risk of developing allergic reactions
CONCLUSIONS: Considering the potentially life-saving benefits of vaccination in a global pandemic environment, it is a safe and effective method to administer vaccines to at-risk patients using desensitization or split dosing techniques, based on their sensitivity status determined through a PEG skin test. This approach allows for the avoidance of preventing access to vaccines, while still ensuring the safety of patients.PMID:37345399 | DOI:10.5578/tt.20239920
Source: Tuberkuloz ve Toraks - June 22, 2023 Category: Respiratory Medicine Authors: Şeyma Özden Fatma Merve Tepetam Özge Atik Source Type: research

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